Atropisomerism in the 2-arylimino-N-(2-hydroxyphenyl)thiazoline series: influence of hydrogen bonding on the racemization process.


A series of original atropisomeric iminothiazolines 1 in which X = OH or (and) Y = OH were prepared from the corresponding methoxy precursors. The resolution of the atropisomeric enantiomers on chiral support is reported, and the barriers to enantiomerization are given. These barriers were determined either by off-line racemization studies or by treatment… (More)