Corpus ID: 21402824

Atropine substitutes and the writhing syndrome in mice.

  title={Atropine substitutes and the writhing syndrome in mice.},
  author={M. S. Kelkar},
  journal={Archives internationales de pharmacodynamie et de therapie},
  volume={229 1},
  • M. S. Kelkar
  • Published 1977
  • Medicine
  • Archives internationales de pharmacodynamie et de therapie
The mouse writhing test has been used to evaluate analgesic drugs. In the present work the protective effect of atropine sulfate and eight of its substitutes was studied against acetic acid-induced writhing in mice. This was compared with the protection afforded by noramidopyrine, a non-narcotic analgesic. Both the time of onset of writhing and the number of writhes over a period of 15 min was recorded. The results seem to indicate some correlation between chemical structure and protective… Expand
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