Atropine, scopolamine, and Ditran: Comparative pharmacology and antagonists in man

@article{Ketchum1973AtropineSA,
  title={Atropine, scopolamine, and Ditran: Comparative pharmacology and antagonists in man},
  author={James S. Ketchum and Frederick R. Sidell and Edward B. Crowell and George K. Aghajanian and Arthur Hull Hayes},
  journal={Psychopharmacologia},
  year={1973},
  volume={28},
  pages={121-145}
}
Atropine, scopolamine, and Ditran, three centrally active anticholinergic compounds, were administered to 158 normal young males in a dose range broader than any previously reported to study serially their central and peripheral effects. The findings indicate that there are not qualitative differences in the actions of these compounds, but there are differences in potency, relative central affinity, and time course of effects. The toxicity of belladonna-related substances responds well to… CONTINUE READING

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