Atrophy of the substantia innominata on magnetic resonance imaging predicts response to donepezil treatment in Alzheimer's disease patients.

@article{Tanaka2003AtrophyOT,
  title={Atrophy of the substantia innominata on magnetic resonance imaging predicts response to donepezil treatment in Alzheimer's disease patients.},
  author={Yuriko Tanaka and Haruo Hanyu and Hirofumi Sakurai and Masaru Takasaki and Kimihiko Abe},
  journal={Dementia and geriatric cognitive disorders},
  year={2003},
  volume={16 3},
  pages={119-25}
}
To investigate whether atrophy of the substantia innominata as shown on magnetic resonance imaging (MRI), reflecting degeneration of cholinergic neurons in the nucleus basalis of Meynert, predicts response to donepezil treatment in patients with Alzheimer's disease (AD), we studied correlations between the thickness of the substantia innominata and clinical efficacy. Eighty-two patients were divided into responders, including transiently and continuously responding groups, and nonresponders… CONTINUE READING

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