Atrophy of the substantia innominata on magnetic resonance imaging and response to donepezil treatment in Alzheimer's disease.

@article{Hanyu2002AtrophyOT,
  title={Atrophy of the substantia innominata on magnetic resonance imaging and response to donepezil treatment in Alzheimer's disease.},
  author={Haruo Hanyu and Yuriko Tanaka and Hirofumi Sakurai and Masaru Takasaki and Kimihiko Abe},
  journal={Neuroscience letters},
  year={2002},
  volume={319 1},
  pages={33-6}
}
Atrophy of the substantia innominata on magnetic resonance imaging (MRI), reflecting degeneration of cholinergic neurons in the nucleus basalis of Meynert, may be an in vivo marker of cholinergic damage. We attempted to investigate whether the MRI features of the substantia innominata predict response to donepezil treatment in Alzheimer's patients. The thickness of the substantia innominata was measured on the coronal T2-weighted MRI through the anterior commissure. Seventy-two patients treated… CONTINUE READING