Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer disease.

@article{Bobinski1995AtrophyOH,
  title={Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer disease.},
  author={Matthew Bobinski and Jarek Wegiel and Henryk M. Wiśniewski and Michal Tarnawski and Barry Reisberg and B. Mlodzik and Mony J de Leon and Douglas Craig Miller},
  journal={Dementia},
  year={1995},
  volume={6 4},
  pages={
          205-10
        }
}
The hippocampal formations of 13 subjects with severe Alzheimer disease [AD; Global Deterioration Scale (GDS) stage 7] and of 5 age-matched subjects without symptoms of dementia were reconstructed from serial sections. Functional assessment staging (FAST) was used at the time of demise to assess 9 patients at stages 7a-c (incipient averbal and nonambulatory) and 4 patients at stages 7e-f (immobile). The duration of the disease from FAST stage 5 until demise ranged from 2 to 8 years in the first… CONTINUE READING

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