Atrophy limited to the third ventricle in chronic schizophrenic patients. Report of a controlled series.

Abstract

Computed tomographic scans of 30 chronic schizophrenic patients and 26 matched medical controls were blindly assessed for ventricular brain ratio, cortical atrophy, third-ventricle diameter, and cerebellar atrophy. Schizophrenic patients had significantly larger third ventricles than the medical controls. There was no difference in the other brain morphologic variables. Phenomenology, drug response, CSF levels of 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, and a wide variety of clinical variables did not correlate with any measure of brain morphology. Clinicopathologic correlates of brain morphology may be limited to those patients with significant atrophy.

Cite this paper

@article{Boronow1985AtrophyLT, title={Atrophy limited to the third ventricle in chronic schizophrenic patients. Report of a controlled series.}, author={John J Boronow and David Pickar and Philip T Ninan and Ananya Roy and Daniel W. Hommer and Markku Linnoila and Shipra Paul}, journal={Archives of general psychiatry}, year={1985}, volume={42 3}, pages={266-71} }