Atrophic cardiomyocyte signaling in hypertensive heart disease.

  title={Atrophic cardiomyocyte signaling in hypertensive heart disease.},
  author={German Kamalov and W. Vivienne Zhao and Tieqiang Zhao and Yao Sun and Robert A. Ahokas and Tony N. Marion and Fahed Al Darazi and Ivan Gerling and Syamal K. Bhattacharya and Karl T. Weber},
  journal={Journal of cardiovascular pharmacology},
  volume={62 6},
Cardinal pathological features of hypertensive heart disease (HHD) include not only hypertrophied cardiomyocytes and foci of scattered microscopic scarring, a footprint of prior necrosis, but also small myocytes ensnared by fibrillar collagen where disuse atrophy with protein degradation would be predicted. Whether atrophic signaling is concordant with the appearance of HHD and involves oxidative and endoplasmic reticulum (ER) stress remains unexplored. Herein, we examine these possibilities… CONTINUE READING
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