Atromentin-induced apoptosis in human leukemia U937 cells.

  title={Atromentin-induced apoptosis in human leukemia U937 cells.},
  author={Jin Hee Kim and Choong Hwan Lee},
  journal={Journal of microbiology and biotechnology},
  volume={19 9},
  • Jin Hee Kim, C. Lee
  • Published 1 September 2009
  • Biology, Chemistry
  • Journal of microbiology and biotechnology
In the course of screening for apoptotic substances that induce apoptosis in human leukemia U937 cells, a fungal strain, F000487, which exhibits potent inducible activity, was selected. The active compound was purified from an ethyl acetate extract of the microorganism by Sep-pak C18 column chromatography and HPLC, and was identified as atromentin by spectroscopic methods. This compound induced caspase-3 processing in human leukemia U937 cells. The caspase-3 and poly (ADP-ribose) polymerase… 
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