Atrioventricular valve development during late embryonic and postnatal stages involves condensation and extracellular matrix remodeling.

@article{Kruithof2007AtrioventricularVD,
  title={Atrioventricular valve development during late embryonic and postnatal stages involves condensation and extracellular matrix remodeling.},
  author={Boudewijn P. T. Kruithof and Steven Krawitz and Vinciane Gaussin},
  journal={Developmental biology},
  year={2007},
  volume={302 1},
  pages={
          208-17
        }
}
Although the signaling molecules regulating the early stages of valvular development have been well described, little is known on the late steps leading to mature fibrous leaflets. We hypothesized that atrioventricular (AV) valve development continues after birth to adjust to the postnatal maturation of the heart. By doing a systematic analysis of the AV valves of mice from embryonic day (E) 15.5 to 8 weeks old, we identified key developmental steps that map the maturation process of embryonic… CONTINUE READING

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