Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation.

Abstract

Safe and effective pharmacologic management of atrial fibrillation (AF) is one of the greatest challenges facing an aging society. Currently available pharmacologic strategies for rhythm control of AF are associated with ventricular arrhythmias and in some cases multi-organ toxicity. Consequently, drug development has focused on atrial-selective agents such… (More)
DOI: 10.1111/j.1749-6632.2009.05086.x

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