Atrial peptides inhibit oxygen consumption in kidney medullary collecting duct cells.

  title={Atrial peptides inhibit oxygen consumption in kidney medullary collecting duct cells.},
  author={Mark Lawrence Zeidel and Julian Lawrence Seifter and Stephanie Lear and Barry M. Brenner and Patricio da Silva},
  journal={The American journal of physiology},
  volume={251 2 Pt 2},
Atrial natriuretic peptides (ANP) stimulate renal Na+ excretion by poorly understood mechanisms, perhaps involving direct inhibition of Na+ transport in the kidney medulla. To examine the effects of ANP on renal cells directly, we prepared highly purified cell suspensions derived from inner and outer medullary collecting duct and thick ascending limb of rabbit kidney and monitored ouabain-sensitive oxygen consumption (QO2). Human ANP diminished QO2 by 27.4 +/- 1.6% (mean +/- SE) in inner… CONTINUE READING


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