Atrial natriuretic peptides and urodilatin modulate proximal tubule Na(+)-ATPase activity through activation of the NPR-A/cGMP/PKG pathway.

@article{Vives2010AtrialNP,
  title={Atrial natriuretic peptides and urodilatin modulate proximal tubule Na(+)-ATPase activity through activation of the NPR-A/cGMP/PKG pathway.},
  author={D. Vives and S{\'i}lvia Farage and Rafael Ot{\'a}vio Cançado Motta and An{\'i}bal Gil Lopes and Celso Caruso-Neves},
  journal={Peptides},
  year={2010},
  volume={31 5},
  pages={903-8}
}
The signaling pathway mediating modulation of Na(+)-ATPase of proximal tubule cells by atrial natriuretic peptides (ANP) and urodilatin through receptors located in luminal and basolateral membranes (BLM) is investigated. In isolated BLM, 10(-11)M ANP or 10(-11)M urodilatin inhibited the enzyme activity (50%). Immunodetection revealed the presence of NPR-A… CONTINUE READING