Atrial natriuretic peptide reduces expression of TNF-alpha mRNA during reperfusion of the rat liver upon decreased activation of NF-kappaB and AP-1.

@article{Kiemer2000AtrialNP,
  title={Atrial natriuretic peptide reduces expression of TNF-alpha mRNA during reperfusion of the rat liver upon decreased activation of NF-kappaB and AP-1.},
  author={Alexandra K Kiemer and Angelika M. Vollmar and Manfred Bilzer and Tobias Gerwig and Alexander L Gerbes},
  journal={Journal of hepatology},
  year={2000},
  volume={33 2},
  pages={236-46}
}
BACKGROUND/AIMS The cardiovascular hormone Atrial Natriuretic Peptide (ANP) attenuates activation of the pro-inflammatory transcription factor NF-kappaB in macrophages. ANP was also shown to protect from ischemia-reperfusion injury of the rat liver. This study aimed to investigate the effects of this immunomodulatory hormone and its second messenger cGMP on the activation of the two redox-sensitive transcription factors AP-1 and NF-kappaB and the expression of corresponding pro-inflammatory… CONTINUE READING

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