Atrial natriuretic peptide in acute hypoxia-induced pulmonary hypertension in rats.

@article{Jin1991AtrialNP,
  title={Atrial natriuretic peptide in acute hypoxia-induced pulmonary hypertension in rats.},
  author={Hee Kyung Jin and R. H.-H. Yang and Yunjia Chen and Robert Max Jackson and Hiroshi Itoh and Masashi Mukoyama and Kazuwa Nakao and Hiroo Imura and Suzanne Oparil},
  journal={Journal of applied physiology},
  year={1991},
  volume={71 3},
  pages={807-14}
}
To test the hypothesis that exogenous atrial natriuretic peptide (ANP) prevents the acute pulmonary pressor response to hypoxia, ANP (20-micrograms/kg bolus followed by 1-microgram.kg-1.min-1 infusion) or vehicle was administered intravenously to conscious rats beginning 3 min before exposure to hypoxia or room air for 90 min. Exogenous ANP abolished the acute pulmonary pressor response to hypoxia in association with marked and parallel increases in plasma ANP and guanosine 5'-cyclic… CONTINUE READING