Atrial natriuretic peptide impairs the stimulatory effect of angiotensin II on H+-ATPase.

@article{OliveiraSouza2002AtrialNP,
  title={Atrial natriuretic peptide impairs the stimulatory effect of angiotensin II on H+-ATPase.},
  author={Maria Oliveira-Souza and Gerhard Malnic and Margarida de Mello-Aires},
  journal={Kidney international},
  year={2002},
  volume={62 5},
  pages={1693-9}
}
BACKGROUND Angiotensin II (Ang II) action on H+-ATPase is not clearly defined, and may vary with renal tubule segment and hormonal doses being studied. Since an increase of cytosolic calcium ([Ca2+]i) can stimulate acid vesicle movement and exocytotic insertion of proton pumps, and it has been shown that Ang II increases [Ca2+]i while atrial natriuretic peptide (ANP) reduces it, there may be some interaction between Ang II and ANP in the regulation of intracellular pH (pHi) mediated by H… CONTINUE READING