Atrial natriuretic factor inhibits central angiotensin II pressor responses.

@article{Casto1987AtrialNF,
  title={Atrial natriuretic factor inhibits central angiotensin II pressor responses.},
  author={Rod Casto and J Hilbig and Gunnar Schr{\"o}der and G{\"u}nter Stock},
  journal={Hypertension},
  year={1987},
  volume={9 5},
  pages={473-7}
}
Intracerebroventricular (i.c.v.) administration of human atrial natriuretic factor (ANF), fragment 1-25, in the dose range 3 to 20 micrograms/kg did not alter resting arterial pressure or heart rate in rats anesthetized with chloralose/urethan (60:600 mg/kg i.p.), while angiotensin II (ANG II), 1 microgram/kg, produced a significant increase in arterial pressure after i.c.v. application. This pressor effect induced by ANG II was abolished by simultaneous administration of ANF (3 micrograms/kg i… CONTINUE READING