Atrial natriuretic factor inhibits angiotensin-, norepinephrine-, and potassium-induced vascular contractility.

@article{Kleinert1984AtrialNF,
  title={Atrial natriuretic factor inhibits angiotensin-, norepinephrine-, and potassium-induced vascular contractility.},
  author={Hollis D. Kleinert and Thomas L Maack and Steven A. Atlas and Andrzej A Januszewicz and Jean E. Sealey and John H. Laragh},
  journal={Hypertension},
  year={1984},
  volume={6 2 Pt 2},
  pages={I143-7}
}
We have previously shown that the natriuretic effect of rat atrial extract (AE) may be due, perhaps entirely, to its powerful renal hemodynamic actions. The present study was undertaken to test the hypothesis that mammalian atria contain a substance that behaves as a functional antagonist of endogenous vasoconstrictors, by examining the direct effects of AE and extensively purified atrial "natriuretic" factor on the contractile response of rabbit aortic rings to angiotensin II (AII… CONTINUE READING
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