Atrial natriuretic factor increases hematocrit and decreases plasma volume in nephrectomized rats.

@article{Almeida1986AtrialNF,
  title={Atrial natriuretic factor increases hematocrit and decreases plasma volume in nephrectomized rats.},
  author={Fo A.P. Almeida and Masashige Suzuki and Thomas L. Maack},
  journal={Life sciences},
  year={1986},
  volume={39 13},
  pages={
          1193-9
        }
}
To test the hypothesis that ANF increases the efflux of fluid from capillaries we determined the effect of synthetic (1-28) ANF on hematocrit (Hct) and plasma volume (PV) in 24 hr bilaterally nephrectomized rats. Results were compared with those obtained in bilaterally nephrectomized rats receiving saline alone (S) or an infusion of sodium nitroprusside (NP) to produce a similar blood pressure lowering effect as ANF. PV was determined by the volume of distribution of RISA 10 minutes after its i… CONTINUE READING

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