Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure.

@article{Cha2004AtrialIR,
  title={Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure.},
  author={Tae-Joon Cha and Joachim R. Ehrlich and Liying Zhang and Stanley Nattel},
  journal={Circulation},
  year={2004},
  volume={110 12},
  pages={1520-6}
}
BACKGROUND Atrial fibrillation (AF) and congestive heart failure (CHF) produce discrete forms of atrial ionic remodeling. The in vivo effects of atrial tachycardia (AT) remodeling are altered by CHF. This study evaluated underlying mechanisms at the level of ionic remodeling. METHODS AND RESULTS We studied 4 groups of dogs: (1) unpaced controls (CTLs); (2) CHF caused by 2-week ventricular tachypacing (VTP, 240 bpm); (3) AT (400 bpm x 7 days); and (4) CHF+AT (2-week VTP with AT for the last 7… CONTINUE READING