Atrial fibrillation produced by prolonged rapid atrial pacing is associated with heterogeneous changes in atrial sympathetic innervation.

@article{Jayachandran2000AtrialFP,
  title={Atrial fibrillation produced by prolonged rapid atrial pacing is associated with heterogeneous changes in atrial sympathetic innervation.},
  author={Jayakrishnan Jayachandran and Haris J. Sih and Webb Van Winkle and Douglas Peter Zipes and G D Hutchins and Jeffrey E. Olgin},
  journal={Circulation},
  year={2000},
  volume={101 10},
  pages={1185-91}
}
BACKGROUND Structural and electrophysiological changes of the atria occur with prolonged rapid rates; however, the effects of sustained atrial fibrillation (AF) on autonomic innervation of the atria are unknown. We hypothesized that electrophysiological remodeling from rapid atrial rates is accompanied by altered atrial autonomic innervation. METHODS AND RESULTS Six dogs (paced group) underwent atrial pacing at 600 bpm; 9 dogs (control animals) were not paced. All paced dogs developed… CONTINUE READING