Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort.

  title={Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort.},
  author={Ulrich Schotten and Maura Greiser and Dirk Benke and Kai Buerkel and Britta Ehrenteidt and Christoph Stellbrink and Jaime Francisco Vazquez-Jimenez and Friedrich Schoendube and Peter Hanrath and Maurits A. Allessie},
  journal={Cardiovascular research},
  volume={53 1},
OBJECTIVE Although AF-induced atrial contractile dysfunction has significant clinical implications the underlying intracellular mechanisms are poorly understood. METHODS From the right atrial appendages of 59 consecutive patients undergoing mitral valve surgery (31 in SR, 28 in chronic AF) thin muscle preparations (diameter<0.7 mm) were isolated. Isometric force of contraction was measured in the presence of different concentrations of Ca(2+) and isoprenaline. To assess the function of the… CONTINUE READING


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