Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major.

@article{Li2008AtrialDA,
  title={Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major.},
  author={Walter Yuan-Hwa Li and Thomas D. Coates and John C. Wood},
  journal={Haematologica},
  year={2008},
  volume={93 2},
  pages={311-2}
}
We measured left atrial size and function from biplane MRI data in 62 adults with thalassemia major. Age-adjusted left atrial ejection fraction was depressed in 7 out of 20 subjects having T2* < 10 ms. Left atrial size, left ventricular size and cardiac output fell with cardiac iron loading, representing increased cardiac or peripheral vascular stiffness.