Atrial Fibrillation-Linked Germline GJA5/Connexin40 Mutants Showed an Increased Hemichannel Function

@inproceedings{Sun2014AtrialFG,
  title={Atrial Fibrillation-Linked Germline GJA5/Connexin40 Mutants Showed an Increased Hemichannel Function},
  author={Yiguo Sun and Matthew D. Hills and Willy G. Ye and Xiaoling Tong and Donglin Bai},
  booktitle={PloS one},
  year={2014}
}
Mutations in GJA5 encoding the gap junction protein connexin40 (Cx40) have been linked to lone atrial fibrillation. Some of these mutants result in impaired gap junction function due to either abnormal connexin localization or impaired gap junction channels, which may play a role in promoting atrial fibrillation. However, the effects of the atrial… CONTINUE READING