Atractylenolide-I Sensitizes Human Ovarian Cancer Cells to Paclitaxel by Blocking Activation of TLR4/MyD88-dependent Pathway

@inproceedings{Huang2014AtractylenolideISH,
  title={Atractylenolide-I Sensitizes Human Ovarian Cancer Cells to Paclitaxel by Blocking Activation of TLR4/MyD88-dependent Pathway},
  author={Jianming Huang and Guo-nan Zhang and Yu Shi and Xiao Zha and Yi Ping Zhu and Miao-Miao Wang and Qing Lin and Wen Wang and Hai-Yan Lu and Shi-Qi Ma and Jia Cheng and Bi-Fang Deng},
  booktitle={Scientific reports},
  year={2014}
}
Paclitaxel, a known TLR4 ligand, leads to activation of TLR4/MyD88-dependent pathway that mediates chemoresistance and tumor progression in epithelial ovarian carcinoma (EOC). Atractylenolide-I (AO-I), a novel TLR4-antagonizing agent, inhibits TLR4 signaling by interfering with the binding of LPS or paclitaxel to membrane TLR4 of human leukocytes. In this study, AO-I was found to attenuate paclitaxel-induced protein expression of IL-6, VEGF and survivin, and to enhance early apoptosis and… CONTINUE READING

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