Atractylenolide Ⅰ protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect.

@article{Tang2017AtractylenolideP,
  title={Atractylenolide Ⅰ protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect.},
  author={Xiao-Mei Tang and Zhi-Kai Liao and You-Wei Huang and Xi Lin and Liang-Cai Wu},
  journal={Asian Pacific journal of tropical medicine},
  year={2017},
  volume={10 6},
  pages={582-587}
}
OBJECTIVE To investigate whether atractylenolide Ⅰ (ATL-Ⅰ) has protective effect on lipopolysaccharide (LPS)-induced disseminated intravascular coagulation (DIC) in vivo and in vitro, and explore whether NF-κB signaling pathway is involved in ATL-Ⅰ treatment. METHODS New Zealand white rabbits were injected with LPS through marginal ear vein over a period of 6 h at a rate of 600 μg/kg (10 mL/h). Similarly, in the treatment groups, 1.0, 2.0, or 5.0 mg/kg ATL-Ⅰ were given. Both survival rate and… CONTINUE READING