Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase).

  title={Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase).},
  author={Hiroko Miyadera and Kazuro Shiomi and Hideaki Ui and Yuichi Yamaguchi and Rokuro Masuma and Hiroshi Tomoda and Hideto Miyoshi and Arihiro Osanai and Kiyoshi Kita and Satoshi O̅mura},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 2},
Enzymes in the mitochondrial respiratory chain are involved in various physiological events in addition to their essential role in the production of ATP by oxidative phosphorylation. The use of specific and potent inhibitors of complex I (NADH-ubiquinone reductase) and complex III (ubiquinol-cytochrome c reductase), such as rotenone and antimycin, respectively, has allowed determination of the role of these enzymes in physiological processes. However, unlike complexes I, III, and IV (cytochrome… CONTINUE READING
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