Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning.

@article{Levano2012Atp8a1DI,
  title={Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning.},
  author={Kelly Levano and Vineet Punia and Michael Raghunath and Priya Ranjan Debata and Gina Marie Curcio and Amit Mogha and Sudarshana Purkayastha and Dan McCloskey and Jimmie E. Fata and Probal Banerjee},
  journal={Journal of neurochemistry},
  year={2012},
  volume={120 2},
  pages={302-13}
}
The molecule responsible for the enzyme activity plasma membrane (PM) aminophospholipid translocase (APLT), which catalyzes phosphatidylserine (PS) translocation from the outer to the inner leaflet of the plasma membrane, is unknown in mammals. A Caenorhabditis elegans study has shown that ablation of transbilayer amphipath transporter-1 (TAT-1), which is an ortholog of a mammalian P-type ATPase, Atp8a1, causes PS externalization in the germ cells. We demonstrate here that the hippocampal cells… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS