Atp-Dependent Adenophostin Activation of Inositol 1,4,5-Trisphosphate Receptor Channel Gating

@article{Mak2001AtpDependentAA,
  title={Atp-Dependent Adenophostin Activation of Inositol 1,4,5-Trisphosphate Receptor Channel Gating},
  author={D. D. Mak and S. Mcbride and J. Foskett},
  journal={The Journal of General Physiology},
  year={2001},
  volume={117},
  pages={299 - 314}
}
  • D. D. Mak, S. Mcbride, J. Foskett
  • Published 2001
  • Chemistry, Medicine
  • The Journal of General Physiology
  • The inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) is a ligand-gated intracellular Ca2+ release channel that plays a central role in modulating cytoplasmic free Ca2+ concentration ([Ca2+]i). The fungal metabolite adenophostin A (AdA) is a potent agonist of the InsP3R that is structurally different from InsP3 and elicits distinct calcium signals in cells. We have investigated the effects of AdA and its analogues on single-channel activities of the InsP3R in the outer membrane of isolated… CONTINUE READING
    37 Citations
    Inositol trisphosphate receptor Ca2+ release channels.
    • 988
    • PDF
    Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating
    • 5
    • PDF
    Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca2+ release channels
    • J. Yang, S. McBride, +4 authors J. Foskett
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2002
    • 197
    • PDF
    Adenophostin A and imipramine are two activators of the olfactory inositol 1,4,5-trisphosphate-gated channel in fish olfatory cilia
    • 8

    References

    SHOWING 1-10 OF 73 REFERENCES
    ATP Regulation of Type 1 Inositol 1,4,5-Trisphosphate Receptor Channel Gating by Allosteric Tuning of Ca2+ Activation*
    • 104
    • PDF
    Adenophostin A Can Stimulate Ca2+ Influx without Depleting the Inositol 1,4,5-Trisphosphate-sensitive Ca2+ Stores in the Xenopus Oocyte*
    • 26
    • Highly Influential
    • PDF
    The inositol 1,4,5-trisphosphate receptor.
    • 154
    • Highly Influential
    Inositol 1,4,5-trisphosphate receptor.
    • K. Mikoshiba
    • Biology, Chemistry
    • Trends in pharmacological sciences
    • 1993
    • 254
    Effect of Adenophostin A on Ca2+ Entry and Calcium Release-activated Calcium Current (I crac) in Rat Basophilic Leukemia Cells*
    • 22
    • PDF
    Effects of adenophostin-A and inositol-1,4,5-trisphosphate on Cl- currents in Xenopus laevis oocytes.
    • 29
    • Highly Influential
    • PDF