Atp-Dependent Adenophostin Activation of Inositol 1,4,5-Trisphosphate Receptor Channel Gating

  title={Atp-Dependent Adenophostin Activation of Inositol 1,4,5-Trisphosphate Receptor Channel Gating},
  author={D. D. Mak and S. Mcbride and J. Foskett},
  journal={The Journal of General Physiology},
  pages={299 - 314}
  • D. D. Mak, S. Mcbride, J. Foskett
  • Published 2001
  • Chemistry, Medicine
  • The Journal of General Physiology
  • The inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) is a ligand-gated intracellular Ca2+ release channel that plays a central role in modulating cytoplasmic free Ca2+ concentration ([Ca2+]i). The fungal metabolite adenophostin A (AdA) is a potent agonist of the InsP3R that is structurally different from InsP3 and elicits distinct calcium signals in cells. We have investigated the effects of AdA and its analogues on single-channel activities of the InsP3R in the outer membrane of isolated… CONTINUE READING
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