Atosiban and nifedipine in the suppression of pre-term labour: A comparative study

@article{Saleh2013AtosibanAN,
  title={Atosiban and nifedipine in the suppression of pre-term labour: A comparative study},
  author={S S Saleh and Muataz Al-Ramahi and Fawaz A Al Kazaleh},
  journal={Journal of Obstetrics and Gynaecology},
  year={2013},
  volume={33},
  pages={43 - 45}
}
This is a retrospective study comparing the efficacy and safety of atosiban and nifedipine in the suppression of pre-term labour. A total of 75 patients were included in this study; 34 received atosiban and 41 received nifedipine. There were no statistically significant differences in the baseline characteristics for both groups. A total of 68.3% of women in the atosiban group remained undelivered at 7 days or more, compared with 64.7% in the nifedipine group, which was not statistically… 

A double-blinded, randomized, placebo-controlled trial assessing the effects of nifedipine on embryo transfer

TLDR
The trial aims to determine whether nifedipine, a CCB with potent smooth muscle relaxing activity and an excellent safety profile, can improve the outcome of ET, and to compare outcomes between the 2 groups for any statistical significance.

Does nifedipine improve outcomes of embryo transfer?

TLDR
This double blinded, randomized, and placebo-controlled trial demonstrated that the single use of 20 mg nifedipine given 30 minutes before embryo transfer did not improve the implantation rate or the clinical pregnancy rate of the infertility treatment.

A double-blinded, randomized, placebo-controlled trial assessing the effects of nifedipine on embryo transfer Study protocol

TLDR
The trial aims to determine whether nifedipine, a CCB with potent smooth muscle relaxing activity and an excellent safety pro fi le, can improve the outcome of ET, to improve the success rate and clinical pregnancy rate.

A Prospective Case–control Trial to Evaluate and Compare the Efficacy and Safety of Atosiban versus Placebo in In vitro Fertilization-embryo Transfer Program

TLDR
Atosiban reduces uterine contractions and increases endomyometrial perfusion, both of which have potential benefits regarding improved IRs, CPR, and ongoing pregnancy rates.

Health, Issues & Care

Pregnancy advancing beyond 40 completed weeks is associated with increased physical risk to both mother and fetus that increases concurrently with gestation. The recommended management for

Systematic review and meta‐analysis of randomized controlled trials of atosiban versus nifedipine for inhibition of preterm labor

  • A. AliA. Sayed M. Abdel-Daim
  • Medicine, Psychology
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2019
Two tocolytic drugs—atosiban and nifedipine—are currently used for first‐line treatment of preterm labor (PTL).

Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro‐inflammatory in labor

TLDR
A pro‐inflammatory role of ENaC is revealed in labor at term and preterm, suggesting it as a potential target for the prevention and treatment of preterm labor.

In silico analysis of the Mus musculus uterine gene expression landscape during pregnancy identifies putative upstream regulators for labour

TLDR
Gene expression profiling of mice uterus from E6.5 to E17.5 results in 7 unique gene expression clusters from early to late pregnancy that define the landscape of molecular events in ongoing pregnancy.

First Do No Harm: Intrapartum Calcium Loading During Oxytocic Induction of Labor

TLDR
The recommended management for pregnancies approaching 42 weeks is a post-dates induction of labour, while induction often involves several stages, the majority of women are ultimately subject to exogenous oxytocin administration.

References

SHOWING 1-10 OF 20 REFERENCES

Atosiban and nifedipine in acute tocolysis: a comparative study.

Atosiban and nifedipin for the treatment of preterm labor

  • M. KashanianA. AkbarianM. Soltanzadeh
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2005

A Prospective Randomized Study Comparing Nifedipine versus Ritodrine for the Suppression of Preterm Labour

TLDR
Nifedipine is recommended for aborting preterm contractions because it has fewer side-effects, superior efficacy and greater ease of administration than intravenous ritodrine.

Atosiban versus betamimetics in the treatment of preterm labour in Germany: an economic evaluation

TLDR
Compared to betamimetics, use of atosiban was associated with a significantly lower frequency of adverse events for tachycardia, palpitation, vomiting, headache, hyperglycaemia, tremor, dyspnoea, chest pain, hypocalemia and foetal tachycardsia.

Developments in the pharmacotherapeutic management of spontaneous preterm labor

TLDR
The pathophysiology of preterm labor and the use of antepartum glucocorticoids are reviewed and the perfect tocolytic does not exist, and clinicians move to nifedipine or atosiban, which are as effective but much safer.

An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue.

TLDR
The treatment of patients in preterm labor with atosiban resulted in prolongation of pregnancy for up to 7 days for those at a gestational age > or =28 weeks, and this occurred with a low rate of maternal-fetal adverse effects.

Nonsteroidal Antiinflammatory Drugs During Third Trimester and the Risk of Premature Closure of the Ductus Arteriosus: A Meta-Analysis

TLDR
Short-term use of NSAIDs in late pregnancy is associated with a significant increase in the risk of premature ductal closure, particularly in women exposed to indomethacin.

Oxytocin receptor antagonists for inhibiting preterm labour.

  • R. Lamont
  • Medicine
    Obstetrics and gynecology
  • 2008
TLDR
The authors of the review were self-appointed and the principal author has published widely on and is a strong advocate of nifedipine and none of the coauthors appear to have publication experience on using oxytocin antagonists.

Management options for preterm labour in Canada.

  • S. KlamL. Leduc
  • Medicine
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
  • 2004

Safety concerns for the use of calcium channel blockers in pregnancy for the treatment of spontaneous preterm labour and hypertension: a systematic review and meta-regression analysis

  • K. KhanJ. Zamora B. Beattie
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2010
TLDR
Adverse event rates generated from this study provide an evidence base for clinical guidelines and informed patient consent for CCB use in pregnancy by a quantitative systematic review.