Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction.

@article{Lau2003AtorvastatinRT,
  title={Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction.},
  author={W C Ivan Lau and Lucy A Waskell and Paul B Watkins and Charlene J Neer and Kevin Horowitz and Amy S Hopp and Alan R. Tait and David G M Carville and Kirk E. Guyer and Eric R. Bates},
  journal={Circulation},
  year={2003},
  volume={107 1},
  pages={32-7}
}
BACKGROUND We observed that the prodrug clopidogrel was less effective in inhibiting platelet aggregation with coadministration of atorvastatin during point-of-care platelet function testing. Because atorvastatin is metabolized by cytochrome P450 (CYP) 3A4, we hypothesized that clopidogrel might be activated by CYP3A4. METHODS AND RESULTS Platelet aggregation was measured in 44 patients undergoing coronary artery stent implantation treated with clopidogrel or clopidogrel plus pravastatin or… CONTINUE READING
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