Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells.

@article{Planavila2005AtorvastatinPP,
  title={Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells.},
  author={Anna Planavila and Rosa Mar{\'i}a S{\'a}nchez and Manuel Merlos and Juan Carlos Laguna and Manuel V{\'a}zquez-Carrera},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1736 2},
  pages={120-7}
}
Although abnormalities in cardiac fatty acid metabolism are involved in the development of several cardiac pathologies, the mechanisms underlying these changes are not well understood. Given the prominent role played by peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta in cardiac fatty acid metabolism, the aim of this study was to examine the effects of nuclear factor (NF)-kappaB activation on the activity of this nuclear receptor. Embryonic rat heart-derived H9c2 cells… CONTINUE READING
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