Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells.

@article{Collisson2003AtorvastatinPR,
  title={Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells.},
  author={Eric A. Collisson and Celina Kleer and Mei Mei Wu and Abhijit De and Sanjiv Sam Gambhir and Sof{\'i}a D. Merajver and Michael S. Kolodney},
  journal={Molecular cancer therapeutics},
  year={2003},
  volume={2 10},
  pages={941-8}
}
Melanoma is a deadly cancer due to its propensity to metastasize. Pharmacological inhibition of cell motility may benefit patients with cutaneous melanoma by preventing metastasis to internal organs. The Rho GTPases are signaling molecules that drive metastasis by controlling cell motility. We found RhoC to be expressed in clinical melanoma specimens and hypothesized that inhibiting its activation might prevent metastasis. Some Rho proteins, such as RhoC, depend on posttranslational… CONTINUE READING
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