Atorvastatin may have no effect on acute phase reaction in children after intravenous bisphosphonate infusion.

Abstract

Intravenous bisphosphonate therapy is associated with acute phase reaction characterized by fever and musculoskeletal pain. Bisphosphonates have been shown in vitro to activate gammadeltaT-cells to proliferate and produce cytokines, suggesting a role in acute phase reaction, which can be effectively blocked by statins. We conducted a double-blind randomized… (More)
DOI: 10.1359/jbmr.081016

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