Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase.

@article{Trebicka2007AtorvastatinLP,
  title={Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase.},
  author={Jonel Trebicka and Martin Hennenberg and Wim Laleman and Nataliya Shelest and Erwin Biecker and Michael Schepke and Frederik Nevens and Tilman Sauerbruch and Joerg Heller},
  journal={Hepatology},
  year={2007},
  volume={46 1},
  pages={242-53}
}
UNLABELLED In cirrhosis, increased RhoA/Rho-kinase signaling and decreased nitric oxide (NO) availability contribute to increased intrahepatic resistance and portal hypertension. Hepatic stellate cells (HSCs) regulate intrahepatic resistance. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) inhibit synthesis of isoprenoids, which are necessary for membrane translocation and activation of small GTPases like RhoA and Ras. Activated RhoA leads to Rho-kinase activation and NO… CONTINUE READING

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