Atorvastatin inhibits osteoclastogenesis by decreasing the expression of RANKL in the synoviocytes of rheumatoid arthritis

@inproceedings{Kim2012AtorvastatinIO,
  title={Atorvastatin inhibits osteoclastogenesis by decreasing the expression of RANKL in the synoviocytes of rheumatoid arthritis},
  author={Jeong Yeon Kim and Eun Young Lee and Eun Bong Lee and Yun Jong Lee and Hyun Jung Yoo and Yeong Wook Song},
  booktitle={Arthritis research & therapy},
  year={2012}
}
INTRODUCTION Statins, hydroxymethylglutaryl-coenzyme A reductase inhibitors, have been reported to have antiinflammatory and/or immunomodulatory effects and prophylactic and therapeutic effects in collagen-induced arthritis, an experimental model of rheumatoid arthritis (RA). The authors undertook to determine the effect of atorvastatin on the expressions of osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) in RA fibroblast-like synoviocytes (FLSs), to identify… CONTINUE READING
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