Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.

@article{Bruemmer2003AtorvastatinIE,
  title={Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.},
  author={Dennis Bruemmer and F. Mei Yin and Joey Liu and Tohru Kiyono and Eckart Fleck and Andre J Van Herle and Kristof Graf and Ronald E. Law},
  journal={European journal of pharmacology},
  year={2003},
  volume={462 1-3},
  pages={15-23}
}
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have been reported to inhibit vascular smooth muscle cell growth, a key event in the pathogenesis of proliferative vascular diseases. The mechanism by which HMG-CoA reductase inhibitors exert their antiproliferative activity is not fully understood, especially their effect on DNA replication. We therefore investigated the effects of atorvastatin on minichromosome maintenance (MCM) protein 6 and 7 expression in vascular smooth… CONTINUE READING