Atorvastatin induces autophagy in prostate cancer PC3 cells through activation of LC3 transcription.

@article{Toepfer2011AtorvastatinIA,
  title={Atorvastatin induces autophagy in prostate cancer PC3 cells through activation of LC3 transcription.},
  author={Nicholas J. Toepfer and Chandra Childress and Ankur Parikh and Daniel B Rukstalis and Wannian Yang},
  journal={Cancer biology & therapy},
  year={2011},
  volume={12 8},
  pages={691-9}
}
Our previous studies have demonstrated that atorvastatin induces autophagy in the androgen receptor negative prostate cancer PC3 cells through inhibition of geranylgeranyl biosynthesis [Parikh et al., Prostate. 70(9): 971-981 (2010)]. This study attempts to elucidate the molecular mechanism underlying atorvastatin-induced autophagy in PC3 cells. PC3 cells were treated with atorvastatin, in combination with the inhibitors for transcription, protein translation, PI-3 kinase, mTOR, and MAP kinases… CONTINUE READING
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