Atorvastatin improving renal ischemia reperfusion injury via direct inhibition of active caspase-3 in rats.


Caspase-3 is a key molecule involved in the inflammation and apoptosis of ischemia reperfusion (IR) injury. Statins are known to inhibit IR injury, but the mechanism of action remains uncertain. In the present study, the effect and underlying mechanism of ischemia alone, and reperfusion with or without atorvastatin (AT) as a timed intervention were examined… (More)
DOI: 10.1258/ebm.2011.010350


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