Atorvastatin improves pathological changes in the aged kidney by upregulating peroxisome proliferator-activated receptor expression and reducing matrix metalloproteinase-9 and transforming growth factor-β1 levels.

@article{Zhao2016AtorvastatinIP,
  title={Atorvastatin improves pathological changes in the aged kidney by upregulating peroxisome proliferator-activated receptor expression and reducing matrix metalloproteinase-9 and transforming growth factor-β1 levels.},
  author={Jiahui Zhao and Qing-li Cheng and Ping Ye and Guang Zhi Yang and Sheng Yun Liu and Qiangguo Ao and Yang Liu and Yazuo Hu},
  journal={Experimental gerontology},
  year={2016},
  volume={74},
  pages={37-42}
}
OBJECTIVE To investigate the effects of atorvastatin (AVT) on renal function and renal pathological changes in the aged rat and explore their possible mechanisms. METHODS Twenty-month-old, normal female Wistar rats were divided into three groups: group A (n=8) was fed high-dose AVT (10mg/kg/d); group B (n=8) was fed low-dose AVT (1mg/kg/d); and group C… CONTINUE READING