Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH

@article{Kimura2010AtorvastatinDS,
  title={Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH},
  author={Yuki Kimura and Hideyuki Hyogo and Sho-ichi Yamagishi and Masayoshi Takeuchi and Tomokazu Ishitobi and Yoshitaka Nabeshima and K. Arihiro and Kazuaki Chayama},
  journal={Journal of Gastroenterology},
  year={2010},
  volume={45},
  pages={750-757}
}
Advanced glycation endproducts (AGEs), final reaction products of protein with sugars, are known to contribute to various disorders, including diabetes, aspects of aging, and neurodegenerative diseases. Recently, we reported elevated levels of serum AGEs in patients with nonalcoholic steatohepatitis (NASH); further, we found that AGEs induced the generation of reactive oxygen species followed by the proliferation and activation of hepatic stellate cells, a major contributor to liver fibrosis… CONTINUE READING
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