Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer’s disease

@inproceedings{Zhang2013AtorvastatinAT,
  title={Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer’s disease},
  author={Yuanyuan Zhang and Yu-Chen Fan and Min Wang and Dong Wang and Xiao-Hong Li},
  booktitle={Clinical interventions in aging},
  year={2013}
}
BACKGROUND AND AIM Amyloid-beta (Aβ) peptide is reported to initiate flexible inflammation in the hippocampus of the human brain in Alzheimer's disease (AD). The present study aimed to investigate the possible effects of atorvastatin on the production of inflammation cytokines in the hippocampus and the potential impacts on behavioral ability, in an AD model. METHODS We firstly established AD rat models using intracerebroventricular injection of Aβ1-42. A Morris water maze was also performed… CONTINUE READING
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