Atorvastatin ameliorates myocardial ischemia/reperfusion injury through attenuation of endoplasmic reticulum stress-induced apoptosis.

@article{Wu2014AtorvastatinAM,
  title={Atorvastatin ameliorates myocardial ischemia/reperfusion injury through attenuation of endoplasmic reticulum stress-induced apoptosis.},
  author={Hui Wu and Qizhu Tang and Jun Yang and Jiawang Ding and Ming Ye and Wusong Dong},
  journal={International journal of clinical and experimental medicine},
  year={2014},
  volume={7 12},
  pages={4915-23}
}
Endoplasmic reticulum stress (ERS) is known to play an important role in mediating myocardial ischemic/reperfusion (I/R) injury. Some previous studies have shown that atorvastatin alleviates myocardial I/R injury in animal models, but whether attenuation of ERS-induced apoptosis contributes to this effect remains to be elucidated. Therefore, in this study… CONTINUE READING