Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia.

@article{Cheng2017AtorvastatinAC,
  title={Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia.},
  author={Wen-pin Cheng and Huey-ming Lo and B Wang and S Chua and M L Lu and Kou-Gi Shyu},
  journal={Journal of the Formosan Medical Association = Taiwan yi zhi},
  year={2017},
  volume={116 5},
  pages={388-397}
}
BACKGROUND/PURPOSE TRB3 (tribbles 3), an apoptosis-regulated gene, increases during endoplasmic reticulum stress. Hypoxia can induce inflammatory mediators and apoptosis in cardiomyocytes. However, the expression of TRB3 in cardiomyocyte apoptosis under hypoxia is not thoroughly known. We investigated the regulation mechanism of TRB3 expression and… CONTINUE READING