Atorvastatin affects leukocyte gene expression in dyslipidemia patients: in vivo regulation of hemostasis, inflammation and apoptosis.

@article{WibautBerlaimont2005AtorvastatinAL,
  title={Atorvastatin affects leukocyte gene expression in dyslipidemia patients: in vivo regulation of hemostasis, inflammation and apoptosis.},
  author={Val{\'e}rie Wibaut-Berlaimont and Anna M Randi and Vanessa Mandryko and Martin W. Lunnon and Dorian O. Haskard and Rossitza P. Naoumova},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2005},
  volume={3 4},
  pages={677-85}
}
BACKGROUND The beneficial effect of HMG-CoA reductase inhibitors (statins) on coronary artery disease has been linked to mechanisms beyond their lipid-lowering effect. However the existence of direct, lipid-independent effects of statin in humans is still controversial. OBJECTIVE To investigate the early effect of atorvastatin on peripheral blood mononuclear cells (PBMC) in dyslipidemic patients using gene arrays. PATIENTS AND METHODS Eleven male patients with primary hyperlipidemia… CONTINUE READING
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