Atorvastatin–Green Tea Interaction: Possible Mechanisms are Complicated, But Clinical Relevance is Not?

@article{Misaka2020AtorvastatinGreenTI,
  title={Atorvastatin–Green Tea Interaction: Possible Mechanisms are Complicated, But Clinical Relevance is Not?},
  author={S. Misaka and K. Shimomura},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2020},
  volume={45},
  pages={423-425}
}
We read with interest a recent article by Abdelkawy et al. in the European Journal of Drug Metabolism and Pharmacokinetics demonstrating that the plasma concentrations of atorvastatin were decreased when orally administered with green tea dry extract (GTE) in 300-mg or 600-mg capsules compared with control (placebo capsule) in healthy volunteers [1]. Atorvastatin is a lipophilic acid-type statin commonly prescribed for hypercholesterolemia. It is mainly metabolized by CYP3A, and is categorized… Expand

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