Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis.

@article{Gittler2013AtopicDR,
  title={Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis.},
  author={Julia K Gittler and James G. Krueger and Emma Guttman-Yassky},
  journal={The Journal of allergy and clinical immunology},
  year={2013},
  volume={131 2},
  pages={300-13}
}
Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in… CONTINUE READING
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