Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide

@article{Shibasaki2015AtomoxetineRL,
  title={Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide},
  author={Yasuhiro Shibasaki and Atsuko Hayata-Takano and Keisuke Hazama and Takahiro Nakazawa and Hirotoshi Hashimoto},
  journal={Neuroscience},
  year={2015},
  volume={297},
  pages={95-104}
}
Attention-deficit/hyperactivity disorder (ADHD) is a complex neurobehavioral disorder that is characterized by attention difficulties, impulsivity, and hyperactivity. A non-stimulant drug, atomoxetine (ATX), which is a selective noradrenaline reuptake inhibitor, is widely used for ADHD because it exhibits fewer adverse effects compared to conventional psychostimulants. However, little is known about the therapeutic mechanisms of ATX. ATX treatment significantly alleviated hyperactivity of… CONTINUE READING

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