Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor ‘knockout’ mice

@inproceedings{Pillidge2014AtomoxetineRH,
  title={Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor ‘knockout’ mice},
  author={Katharine E Pillidge and Ashley J. Porter and Temis Vasili and David J. Heal and S. Clare Stanford},
  booktitle={Pharmacology Biochemistry and Behavior},
  year={2014}
}
BACKGROUND Mice with functional ablation of the neurokinin-1 receptor gene (NK1R(-/-)) display behavioural abnormalities which resemble the hyperactivity, inattention and impulsivity seen in Attention Deficit Hyperactivity Disorder (ADHD). Here, we investigated whether the established ADHD treatment, atomoxetine, alleviates these abnormalities when tested in the light/dark exploration box (LDEB) and 5-Choice Serial Reaction-Time Task (5-CSRTT). METHODS Separate cohorts of mice were tested in… CONTINUE READING