Atomoxetine modulates spontaneous and sensory-evoked discharge of locus coeruleus noradrenergic neurons

@article{Bari2013AtomoxetineMS,
  title={Atomoxetine modulates spontaneous and sensory-evoked discharge of locus coeruleus noradrenergic neurons},
  author={Ausaf Bari and Gary Aston-Jones},
  journal={Neuropharmacology},
  year={2013},
  volume={64},
  pages={53-64}
}
Atomoxetine (ATM) is a potent norepinephrine (NE) uptake inhibitor and increases both NE and dopamine synaptic levels in prefrontal cortex, where it is thought to exert its beneficial effects on attention and impulsivity. At the behavioral level, ATM has been shown to cause improvements on the measures of executive functions, such as response inhibition, working memory and attentional set shifting across different species. However, the exact mechanism of action for ATM's effects on cognition is… CONTINUE READING

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VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 164 REFERENCES

Adrenergic pharmacology and cognition: focus on the prefrontal cortex.

  • Pharmacology & therapeutics
  • 2007
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Low-dose methylphenidate actions on tonic and phasic locus coeruleus discharge.

  • The Journal of pharmacology and experimental therapeutics
  • 2006
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks

  • Biological Psychiatry
  • 2011
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL